The 3D mixing machine is working, due to the multi-directional operation of the mixing barrel, the flow and diffusion of various materials are accelerated during the mixing process, and at the same time, the segregation and accumulation of material specific gravity caused by the centrifugal force of the general mixer are avoided. Excellent mixing results can thus be achieved. It is widely used in the mixing of novel materials in pharmaceutical, chemical, food, light industry and other industries and scientific research units.